Nafisa Hassan Ali, Shahana Urooj Kazmi, Shaheen Faizi.
Activity of synergistic combination Amoxy-cassia against Salmonella.
Pak J Pharm Sci Nov ;20(2):140-5.

The object of this study was to formulate new, cost effective anti-microbial combination for Multi Drug Resistant (MDR) Salmonella enterica Serover Typhi (SEST) based on the synergistic activity of amoxicillin with the aqueous fruit solution of Cassia fistula (CFF), a medicinal plant found in Pakistan which when tested alone have weak antimicrobial activity against blood isolates of MDR SEST. MIC of MDR SEST for amoxicillin and CFF alone was 750µg/ml and 3750µg/ml. The MIC of amoxicillin in combination with CFF was 23.4-187.5 µg/ml and 0.37–1.56 µg/ml for MDR and MDS SEST respectively. Fractional Inhibitory Concentration Index (FICI) using chequer-board titration suggested synergism for 80% MDR and MDS SEST tested, no antagonism observed. Time kill kinetics showed difference > log2 in CFU of CFF having sub-lethal amoxicillin concentrations. This novel combination is named as Amoxy-cassia. In vivo it is found to be non toxic at 1gm/body weight of mice.

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