Farrukh Zahra, Muhammad Younis, Uzma Nisar.
Nonulcer dyspepsia; frequency in young patients and its response to helicobacter pylori eradication and trial of proton pump inhibitors.
Professional Med J Dec ;23(08):907-11.

To determine the frequency of nonulcer dyspepsia in patients presenting with the peptic ulcer like symptoms and to determine the effect of H. pylori eradication on dyspeptic symptoms and the effect of six weeks trial of proton pump inhibitor as treatment measure. Study design: Cross-sectional study. Setting: Combined Military hospital Quetta, Department of medicine. Period: Six months from Oct, till March 2009. Subjects and Methods: Patients coming to medicine department with complaints of dyspepsia. Results: Total no of patients were 145 out of which male were 90 while 55 were females. The mean age was 29.68 + 4.53. These subjects were given H pylori eradication therapy and response was graded as patients responded or no response. 89 subjects (61.4%) responded to H pylori eradication treatment while 56 subjects (38.6%) showed no symptomatic benefit. Non responder to eradication i.e., 37 males and 36 females were given further six week treatment with omeprazole, and subjective response to treatment was graded as complete resolution found in 31 patients ( 21.4% ), while partial resolution was present in 15 patients (10.3%). 07 patients (4.8%) showed no improvement while 03 patients (2.1%) showed worsening of symptoms. Conclusions: The prevalence of non-ulcer dyspepsia is high among symptomatic individuals. The response to H pylori eradication was significant. Non responders also showed considerable symptomatic benefit with PPI. Therefore, individuals with recurrent dyspeptic symptoms should be given trial of H. pylori eradication.

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