Sadia Shakeel, Khan Usmanghani, Allah Nawaz, Shahbaz Ahmad Zakki, Zheng Guo Cui, Shugufta Abrahim, Tanveer Ahmad Mir.
Evaluation of in vitro lipoxygenase inhibition and antioxidant activity of polyherbal formulation entoban.
RADS J Pharm Pharmaceut Sci Nov ;3(2):82-8.

Lipoxygenases are family of iron containing dioxygenases that convert the addition of molecular oxygen to fatty acid containing a cis-1, 4- pentadiene system. The primary product of this reaction is a 4-hydroperoxycis trans-1, 3-conjugated pentadienyl moiety within unsaturated fatty acid. This assay measures the hydroperoxides produced in the lipoxygenation reaction using a purified lipoxygenase with lionoleic acid as substrate. When formulations of Entoban syrup and capsules were compared at various concentrations (10, 50 and 100 µg/ml), lipoxygenase inhibition activity increased in a dose dependent manner for both formulations just like standard bacilein. The formulations under test have good potential of lipoxygenase inhibition and prospective to be used in the treatment of various complications produced by lipoxygenase enzymes.

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