Amina Noor, Hassan Mustafa, Syed Affan Ali, Sumera Kazmi, Nasma Noor, Saqib Malik.
The correlation between plasma D-dimer level and lesion volume in acute ischemic stroke.
J Postgrad Med Inst Nov ;34(2):87-90.

Objective: To find out correlation between serum D-dimer and lesion volume in acute ischemic stroke. Methodology: This cross-sectional study was conducted in Ayub Teaching Hospital, Abbottabad from April 2018 to December 2018. A total of 83 patients with ischemic stroke were enrolled in this study using non-probability consecutive sampling. Diagnosis was made on history, examination and computerized tomography (CT) brain findings. A pre-designed proforma was used to collect data, which was analyzed using SPSS version 20. Descriptive and inferential statistics were applied where needed. Results: Out of 83 patients, the mean age was 52.78 +- 10.37 years with range from 35 to 65 years. In total, 64 (77.11%) were males. Infarct volume on CT ranged from 18.00 to 192.00 cc with mean of 74.10 +- 35.02 cc. Plasma D-dimer level ranged from 10 to 200 ug/l with mean of 80.23 +- 54.65. Gender stratification of age, infarct volume and plasma D-dimer in male revealed means of 53.41 +- 10.30, 74.01 +- 34.98, and 82.20 +- 55.64 respectively, while in females means were recorded as 50.68 +- 10.58, 74.42 +- 36.11, and 73.58 +- 52.08 respectively. The correlation statistics, between infarct volume and plasma D-dimer level revealed significant positive correlation (r=0.537; p=<0.001). Correlation was further stratified based on gender and a significatly positively corelation coefficient was found. Conclusion: Significant positive correlation was found between plasma D-dimer and lesion volume in acute ischemic stroke.

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