Usman Nasir, Aafrinish Amanat, Maria Aslam, Muhammad Tahir Saeed, Sadaf Munir.
Comparison of ADAMTS13 Levels in patients of Acquired Thrombotic Thrombocytopenic Purpura and Disseminated Intravascular Coagulation.
J Sharif Med Dent Coll Dec ;5(2):56-9.

Objective: To compare ADAMTS13 levels in patients of acquired thrombotic thrombocytopenic purpura (TTP) and disseminated intravascular coagulation (DIC). Methodology: This cross-sectional comparative study was carried out in the Haematology Department of Shaikh Zayed Hospital, Lahore after approval from the ethical review board. A total of 64 diagnosed cases of acquired TTP and DIC of both genders and age >=15 years were included in the study by consecutive sampling technique. The included patients were allocated into two groups. Group A comprised of 32 diagnosed patients of TTP and group B included 32 diagnosed patients of DIC. After taking written informed consent and using aseptic measures, 5 ml of venous blood was drawn from each study participant. The ADAMTS13 levels were estimated by enzyme-linked immunosorbent assay technique (ELISA). The data was entered and analyzed by using the Statistical Package for the Social Sciences (SPSS) version 23.0. Results: In group A, there were 5(15.6%) males and 27(84.4%) females. In group B, 14(43.8%) patients were males and 18(56.3%) were females. The levels of ADAMTS13 were low in 17(53.12%) patients in group A and 6(18.75%) patients in group B. This difference was statistically significant (p<0.004). Conclusion: The ADAMTS13 levels were low in 53.12% patients of TTP and 18.75% patients of DIC. There exists a remarkable difference in the levels of ADAMTS13 in patients of acquired TTP and DIC. Keywords: Thrombotic thrombocytopenic purpura. Disseminated intravascular coagulation. ADAMTS13.

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