Safeena Sidiq, Talha Laique, Ayesha Ahmad, Kashif Butt, Jahanzaib Khan, Maryam Rashid.
Nephroprotective Effect of Methanolic Extract of Dinothrombium Tinctorium in Albino Rats.
J Akhtar Saeed Med Coll Nov ;1(3):107-10.

Modern world has proven scientifically that medicines derived from animals are important tools in treating ailments today. Objective: in current project, goal was to estimate the nephro-protective effects of methanolic extract of Dinothrombium tinctorium against carbon tetrachloride-induced nephrotoxicity. Study design: It was a randomised control study. Methodology: Aqueous methanolic extract (70% v/v) of Dinothrombium tinctorium (Dt.Cr) was arranged followed by subsequent evaporations. Renal toxicity was induced by CCl4 (2 ml/kg, p.o) in paraffin oil on 7th day of experiment. Administration of methanolic extract of Dinothrombium tinctorium (300mg/kg body weight/day) orally sheltered the CCl4 caused elevation of renal serum markers that include urea and creatinine. There was renal markers elevation in the CCl4 alone treated animals. Results: Administration of methanolic extract to CCl4 encounter protection against the renal toxicity. Conclusion: thefindings thus suggested that this methanolic extract can be used as nephroprotective agent against CCl4-induced renal toxicity in albino rats. Key Words: Urea, Creatinine, Medicine

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