Syed Rashid-ul Amin, Nada Aziz, Saba Jamal, Uzma Ali, Faraz Khaskheli.
18F a better alternative of 68ga for radio labeling of PSMA to detect prostate cancer lesions - a comparative analysis.
Pak J Radiol Nov ;34(3):141-8.

OBJECTIVE: Our study aims to compare the tumor-related PSMA-ligand uptake and detection efficiency of 18F-PSMA-1007 and 68Ga-PSMA-11 PET/CT in biopsy-proven primary, metastatic, and biochemically recurrent PCa. It determines whether 18F and 68Ga are interchangeable for radiolabeling of PSMA. MATERIAL AND METHODS: This comparative study includes 40 patients who underwent 18 F-PSMA-1007 PET/CT, matched with a cohort of 40 patients with similar clinical parameters (Gleason score TNM stage and PSA level) who underwent 68 Ga-PSMA-11 PET/CT. Two experienced nuclear medicine physicians reported all images (n=80). The SUVmax of lesions with the highest uptake were noted and compared distinctively. RESULTS: 18 F-PSMA-1007 and 68 Ga-PSMA-11 both revealed 111 and 105 PSMA positive lesions respectively. The results for local recurrence, lymph node metastasis bone, and other uptake for both radiopharmaceuticals were 36.19%, 19.04%, 44.76%, and 3.8% for 68 Ga-PSMA-11 and 35.13%, 30.63%, 34.23% and 6.30% for 18 F-PSMA-1007. It is observed that 18 F-PSMA-1007 detected a higher number of abdominopelvic lymph nodes than 68 Ga-PSMA-11 due to its different clearance routes and good spatial resolution. Whereas, results for other regional metastasis detection were comparable for both radiopharmaceuticals. CONCLUSION: The results were comparatively alike for both radiotracers. However, 18 F-PSMA-1007 revealed more primary PCa lesions and lymph nodes in the pelvis due to its minimal background activity at the bladder and ureter. KEYWORDS: PET/CT (positron emission tomography/ computed tomography), 18 F - PSMA-1007, 68 Ga-PSMA-11, PCa Prostate cancer.

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