Azra Parveen, Arzoo Fatima, Ahmad Qureshy, Abubaker Shahid.
Diagnostic edge of SPECT/CT scintigraphy over planar bone imaging for detection of bone metastases in prostate cancer patients.
Pak J Nuclear Med Nov ;13(1):31-6.

Background: Bone scintigraphy with 99mTc-labelled diphosphonates can identify prostate cancer (PCa) bone metastases with high sensitivity but relatively low specificity. Single photon emission computed tomography /computed tomography (SPECT/CT) can add value to the planar bone scintigraphy in the detection of bone metastases. Case Presentation: We present a diagnosed case of prostatic adenocarcinoma of a 62 years old male patient who underwent 99mTc-Methyldiphosphonate planar bone scintigraphy followed by SPECT/CT as a part of the staging algorithm. Planar bone imaging showed homogeneous and symmetrical tracer uptake throughout the visualized skeleton. As the patient had complaints of urinary obstruction and severe backache: so, the sacrum could not be adequately assessed on planar bone imaging; therefore SPECT/CT of the lumbar spine and the pelvic region was performed. His regional SPECT-CT study of the lumbar and pelvic region, revealed widespread diffuse tracer avid osteoblastic lesions throughout the visualized lower lumbar spine, sacrum, pelvis, and proximal femori, suggestive of skeletal metastases. Conclusion: We conclude that SPECT/CT scintigraphy has a diagnostic edge over planar bone imaging in detecting bone metastases in PCa patients.

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