Abdul Rehman.
Clinical resistance to Nalidixic acid among children 6-36 months old, reporting with dysentery.
Pak Paed J Nov ;29(2):89-91.

Objective: To determine the age and gender distribution of resistance to nalidixic acid in children (aged 6 to 36months) suffering from dysentery. Design: Observational study. Setting: Pediatric department of Tehsil Headquarter Hospital Liaquetpur. Patients and Methods: Children aged 6 to 36 months with a clinical diagnosis of dysentery were included. All the children were given nalidixic acid (15mg/kg 4 times a day). If the stool was still bloody after 48 hours, the case was labeled as resistant to nalidixic acid. Results: Nalidixic acid was given to 300 cases, out of which 195 (65%) were males and 105 (35%) were females. Fifty two (17.3%) belonged to age group 6-12 months, 158 (52.67%) to age group +12-24 m and 90 (30%) to age group +24- 36 m. The clinical response (no visible blood in the stool) at the end of 48 hours was seen in 245 (81.67%) cases and the resistance was found in 55 (18.33%) cases. Out of 55 resistant cases 34 (61.82%) were male and 21 (38.18%) were females. 10 (18.18%) belonged to age group 6-12 m, 31 (56.36%) to age group +12- 24 m and 14 (25.46%) to age group +24-36 m. Conclusion: Clinical resistance to nalidixic acid in children with dysentery was found to be high in our hospital. Appropriate measures should be taken to diagnose and treat young patients with dysentery.

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