Ghulam Rehmani Lakho, Zeba Haq, Jalauddin Akber, Tariq Chundrigar, Masood Anwar Qureshi.
Relationship between maternal and cord blood leptin levels in Pakistani subjects.
Pak Paed J Jan ;30(2):95-100.

Objective: To ascertain the relationship between maternal serum leptin levels and cord blood leptin levels of Pakistani subjects at delivery, and to determine the relationship of parity with maternal and cord blood leptin levels. Setting: Lady Dufferin Hospital and Ziauddin Hospital Karachi. Methods: leptin concentration was measured in 110 normal full term pregnant subjects between 18 and 35 years of age, using Active Elisa Kit (DSL-10-23100). Samples were selected according to availability. Results: Mean maternal serum leptin levels were 27. 9 ± 18.1 ng/ml. Mean cord blood leptin levels were 10.0 ± 7.5 kg/m2, Maternal serum leptin was found to be positively correlated with cord blood leptin (r = 0.67, p < 0.01). The average maternal and cord blood leptin levels of multigravida (n = 75) subjects were higher than primigravida (n = 35). Conclusion: Cord blood leptin levels increases with increase in maternal level. High leptin level gradient exist between maternal and cord leptin. The increase in maternal and cord blood leptin in multigravida mothers is accounted possibly by the difference in fat cells between primigarvida and multigravida subjects.

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