Jalbani G A, Aamir K, Unar M A, Shaikh A M, Ashraf R, Soomro F M.
To evalulate and compare the effects of first generation anti-histamine (chlorpheniramine maleate) and second generation anti-histamine (cetirizine dihydrocholoride) on isolated trachea of Rabbit.
Med Channel Jan ;12(1):56-60.

The purpose of study was to evaluate the antagonostic effects of chlorpheniramine maleate and cetirizine dihydrochloride on histamine induced contractions in isolated trachea of rabbit and to compare the effects of first generation anti-histamine (chlorpheniramine maleate) and second generation anti-histamin (cetirizine dihydrochloride) on isolated trachea of rabbit. MATERIALS AND METHODS: In this study twenty-four experiments were performed on isolated trachea of rabbit, in the presence of selected standard concentration of histamine dihydrochloride antagonistic effects of various concentrations of chlorpheniramine male-ate (10e-18 to 10e-3 gm/ml) and cetirizine dihydrochloride from concentrations to 10-3 gml ml were recorded by Polygraph Model 7B in terms of rate and amplitude. Results: Chlorphenimmine maleate showed non-significant antagonistic effect from concentrations 10e-18 to 10e-9 gm/ml in case of rate and 10e-18 to 10e-8 gm/ml in case of amplitude. Significant response showed from concentrations 10e-8 to 10e-3 gm/ml in care of rate (P<0.001) and 10e-7 to 10e-3, gm/ml in case of amplitude (P<0.001) while, cetirizine showed non-significant response front concentrations to , gm/ml in case of rate and 10e-18 to 10e-12 gm/ml in case of amplitude. Significant response observed from concentrations 10e-12 to 10e-3 gm/ml in case of rate (P<0.001) and 10e-11 to 10e-3 gm/ml in case of amplitude (P<0.001). CONCLUSION: It was concluded that chlorpheniramine maleate antagonized thetukl tisatnmd mine induced contractions 80.65% at concentration la, gm/ml in case of amplitude 11.35% at concentration 10e-3 gm/ml in case of rate and cetirizine dihydrochloride 82.69% in case of amplitude and 12.33% in case of rate.

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