Munawar Alam Ansari, Shahida P Ahmed, Anila Kazi.
Role of D-2 receptor antagonist Chlorpromazine in observer rated signs of acute opioid abstinence syndrome.
J Basic Applied Sci Jan ;3(1):39-42.

Chlorpromazine is very common non-opioid treatment option for acute opioid abstinence syndrome at different hospitals and detoxification centers at Karachi. Hence the study was conducted to investigate the efficacy of chlorpromazine compared with placebo in acute opioid abstinence syndrome. Forty healthy opiate-dependent patients seeking inpatient treatment were selected randomly. Of the 40 study patients, 20 were given placebo and 20 were given chlorpromazine 150 mg/day in divided doses under single blind protocol. All patients completed the treatment program and stayed in the hospital for 10 days. Chlorpromazine is ineffective treatment to control the signs of acute opioid abstinence syndrome. There were non- significant differences in the cumulative scores of signs of acute opioid abstinence syndrome between the two groups. The investigators found no benefit of chlorpromazine over placebo in treating acute opioid abstinence syndrome

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