Lubna Amer, Rukhshan Khurshid, Bushra Farooqi, Abdul Hameed Khan.
To study the effects of Amlodipine (calcium channel blocker) on lipid profile in hypertensive patients.
Proceeding Shaikh Zayed Postgrad Med Inst Jan ;17(2):61-6.
Amlodipine belongs to the dihydropyridine subclass of calcium antagonist. It is a potent peripheral and coronary vosodilator with selectivity for vascular smooth muscle and minimal effect on myocardial contractility or cardiac conduction. Forty patients (20 male and 20 female) with mild or moderate essential hypertension were selected. Blood pressure was controlled in twenty-five patients with 5 mg dose of Amlodipine and in fifteen patients with 10 mg in twelve weeks. Serum Cholesterol, serum Triglycerides and serum Lipoprotiens (HDL, LDL) was carried out by Standard kit methods (Merck). Mean blood pressure of both male and female was significantly reduced. Present study observed non-significant variation in the mean values of serum triglyceride and serum HDL-Cholesterol and significant variation in the mean values of serum cholesterol and serum LDL- Cholesterol levels before and after Amlodipine treatment in male and female patients on either 5 mg or 10 mg of Amlodipine. It is therefore concluded that Amlod ipine is an antihypertensive drug having some lipid lowering effects.
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