Ghulam Ali Qureshi, Aftab A Qureshi, Shuja Ali Syed, Parvez S H.
Coexistence of neurotransmitters in Parkinson`s disease.
Pak J Neurological Sci Jan ;2(2):85-91.

Parkinson`s disease is a neurological disorder of older individuals frequently encountered in clinical practice. Disparate etiologic factors including infectious agents, genetic predisposition, environmental and toxic factors, metabolic abnormalities, traumatic events, electromagnetic radiation exposure, antioxidants, sex hormones, pharmaceutical drugs and others have been proposed. In this study, cerebrospinal fluid obtained by lumbar puncture is used to assess levels of neurotransmitters in Parkinson`s disease patients treated with L-dopa during On and Off periods. We found a correlation between small peptides such as neuropeptide Y, substance P and cholecystokinin (both octa- and tetra- peptides) with the classical neurotransmitters such as norephinepherine, dopamine and serotonin.

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