Ahmed Jasim Alhusaynei, Isam Hamo Mahmood, Zena Sattam.
Comparison of the effects of Cabergoline and Bromocriptine in women with Hyperprolactinemic Amenorrhea.
Pak J Med Health Sci Jan ;1(1):24-7.

Background: Dopamine agonists are the preferred treatment for most patients with hyperprolactinemic disorders, these agents are extremely effective in lowering serum prolactin levels, eliminating galactorrhea, restoring regular menses and decreasing tumor size . Dopamine agonists, including bromocriptine, quinagolide and cabergoline are differ in their efficacy and tolerability. However, there are relatively few reports in the world comparing the beneficial and adverse effects of bromocriptine and cabergoline in the treatment of hyperprolactinemic patients and there is also lack of such studies in Iraq. Therefore, this study sets out to compare the efficacy and safety of cabergoline with those of bromocriptine in women with hyperprolactinemic amenorrhea in Mosul city. Patients and methods:One hundred and thirty women with hyperprolactinemic amenorrhea were treated with either cabergoline (0.5 mg weekly) or bromocriptine (2.5 mg twice daily ) administerd randomly for 8 weeks. Clinical & biochemical status was assessed at baseline and at the end of trial. Results: Amenorrhea persisted in 9 women of the cabergoline-treated women and 20 of the bromocriptine-treated women. Galactorrhea disappeared in the cabergoline group and persisted in 12 of the bromocriptine group. Normoprolactinemia was achieved in 87.7% women treated with cabergoline and in 67.7% of women treated with bromocriptine. The reduction of prolactin level is statistically higher in the cabergoline group compared with the bromocriptine group. Conclusion: cabergoline and bromocriptine are effective in the treatment of hyperprolactinemic amenorrhea .Cabergoline has the advantage over bromocriptine in terms of both efficacy and tolerability and therefore it is preferred in the treatment of hyperprolactinemic amenorrhea.

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