Muhammad Hafeez, Shaharyar, Abrar Ad Javed, Abid Jamil, Ijaz Hussain Shah, Abubaker Shahid, Shaheena Perveen, Ahmed Ijaz Masood, Khalid Shabbir, Shaid Rasool.
Rationale of laryngeal conservation with induction Chemotherapy followed by concomitant chemo radiotherapy in resectable stage III and IV cancer of Larynx and Hypopharynx.
Pak J Med Health Sci Jan ;1(2):52-3.

Squamous cell carcinoma of head and neck is a common clinical problem in Pakistan. The age standardized incidence rate of laryngeal cancer alone is 9.4 in Karachi. This is the highest rate in Asia and it constitutes 5.8% of all cancers in men. The age standardized incidence rate of pharyngeal cancer is 7.9 and it constitutes 5.0% of all cancers in men1. These are comparatively less common in females. Loco regionally advanced presentation is not uncommon in laryngo pharyngeal cancer. Surgical resection in these patients leads to major cosmetic deformities and loss of function of normal speech or swallowing in many. Patients with unresectable disease have poor prognosis. Chemotherapy alone has the potential to induce complete responses in loco regionally advanced disease but it offers little or no chance of cure or long-term control. Standard fractionated radiotherapy and hyper fractionated radiotherapy can achieve a good local control but the cure is infrequently achieved. The optimum methods of utilizing these approaches have not been established.

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