Tahira Tasneem, Abdul Rashid, Saeed Akhtar, Saeed Ahmed.
Argyrophilic Nuclear Organizer Regions (AgNORs) in Lymphocytic Leukaemia.
Ann King Edward Med Uni Jan ;7(4):288-90.

Nuclear organizer regions code for ribosomal RNA and are associated with non-histone nucleoproteins that can be identified by silver staining (AgNORs). AgNORs have been correlated to proliferative activity of tumours. The present study was carried out to observe the AgNOR pattern in lymphocytic leukaemias. A significant increase in AgNOR counts (p<0.001) was observed in acute lymphoblastic leukaemia (ALL) patients as compared to normal controls. The proliferative index was found to be significantly higher in ALL. In chronic lymphocytic leukaemia and reactive lymphocytes, AgNOR pattern was found similar to the normal lymphocytes. These resells suggest that AgNORs counts are significantly higher in acute lymphoblastic leukaemia.

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