Abdur Rahman, Nagi A H, Abdul Hayee.
Effects of cobra venom on blood coagulation, platelets & fibrinolysis.
Pak J Med Health Sci Jan ;1(3):106-10.

The effects of Cobra Venom (CV) on blood coagulation, platelets and fibrinolytic enzyme system were studied after injecting 1 MLD, 0.5 MLD & 0.1 MLD CV intramuscularly in rabbits. Thrombocytopenia was the earliest change to appear. No prolongation of Prothrombin Time (PT), Activated partial thromboplastin Time (APTT) and Thrombin Time (TT) was seen in any of these animals. Fall in fibrinogen levels and raised levels of FDPs were noted indicating activation of fibrinolysis. RBC Morphology was unchanged in all these animals. Reticulocyte counts also remained unchanged. On histological examination lungs, liver and kidneys showed intravascular clotting and cellular damage.

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