Najma Naz, Giiulam Rasool Mashoori, Tabassum Zehra, Afshan Chaudhry, Jamil Lagha Ri.
Intra venous iron sucrose versus oral ferrous sulphate for treatment of iron deficiency anemia in Pregnancy.
Med Channel Jan ;14(1):55-8.

OBJECTIVE: To compare the efficacy of iron sucrose with ferrous sulphate for treatment of iron deficiency anemia during pregnancy BACKGROUND: Iron supplementation is a commonly used strategy to meet the increased requirements of at-risk groups, such as women of child bearing age, especially during pregnancy. Currently no single approach may be universally acceptable although a moderate iron dosage protocol will likely provide the most benefit to those who require supplemental iron. MATERIAL AND METHOD: A total of 90 pregnant women with haemoglobin level 810g/dl, in their gestation period of 12-28 weeks, were divided into two groups. Group A received ferrous sulphate (oral) 200mg three times a day for 60 days, Group B received iron sucrose (intravenous). Dose of Iron sucrose was calculated according to formula. Treatment efficacy was assessed by measuring haemoglobin and serum ferritin at day 0 and day 60. RESULT: Both regimens were effective and increase in haemoglobin was observed, rising from 8.82±0.08 g/dl to 11.74±0.070g/dl with iron sucrose on day 60 and from 9.1±0.075g/d1 to 11.08±0.090 with iron sulphate on day 60.Group B (iron sucrose) shows significantly higher value of haemoglobin. ferritin values were also higher in patients receiving intravenous iron. The overall adverse effects were more common in the ferrous sulphate group as compared to iron sucrose group. CONCLUSION: The results of the present study suggest that iron sucrose can be considered as a useful alternative treatment for iron deficiency anemia during pregnancy, with no serious adverse reactions.

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