Ziauddin A Kashmiri, Raheel Hussain, Farzana Kausaur, Shoaib Ahmed Ganghat.
Hemodynamic response to Laryngoscopy & Endotracheal intubation, a comparison between induction by injection midazolam & injection thiopentone sodium.
Med Channel Jan ;13(4):6-9.

OBJECTIVE: The objective of this study was to compare the haemodynamic response to laryngoscopy & Endotracheal Intubation after intravenous induction with Injection Midazolam & Injection Thiopentone Sodium. STUDY DESIGN: This was prospective, single blinded, comparative, randomized study. PLACE OF STUDY: This Study was conducted in the department of Anaesthesiology and Surgical I.C. U of Civil Hospital Karachi, D. U.H.S, over a period of more than one year. PATIENTS & METHOD: 200 randomly selected A.S.A I & II patients with Mallampati class I, receiving general anaesthesia were divided into 2 groups, 100 patients in each group, Group I, receiving Injection Midazolam & the other group, Group II, receiving Injection Thiopentone Sodium, as an intravenous induction agent, after laryngoscopy & intubation all patients were monitored for 5 minutes for any change in their Heart Rate & Mean Arterial Pressure. These hemodynamic changes were observed & noted in the proforma by an independent observer who had no knowledge as to which group the patient actually belonged to. These changes in the Heart Rate & Mean Arterial Pressure were recorded after 1st minute, 2nd minute, 3rd minute, 4th minute & 5th minute. RESULTS: As can be seen from the tables I, II, III, IV, the increase in Mean Arterial Pressure (MAP) was more common in the Midazolam group & the increase in Heart Rate was more common in the Thiopentone Sodium (STP) group. CONCLUSION: We conclude that injection Midazolam is more associated with the increase in MAP as compared to injection STP & STP is associated with more increase in Heart Rate as compared to Midazolam, in response to Laryngoscopy & Endotracheal Intubation.

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