Rubina Ad Memon, Razia Bahadur Khero, Gulam Nabi Memon.
Use of misoprostol in cervical ripenieng prior to instrumention in first trimester of the Pregnancy.
Med Channel Jan ;13(4):34-6.

OBJECTIVE: Surgical termination of the pregnancy leads to various morbidities. Use of misoprostol prior to instrumentation reduces such risks. Study was conducted to assess the efficacy of misoprostol for cervical ripening prior to instrumentation. DESIGNING & SETTING: Observational study conducted in department of Obstetric & Gynecology at Nawabshah Medical College Hospital Nawabshah from January 2003 to December 2004. MATERIAL & METHODS: 100 eligible women received intravaginal misoprostol 200 – 800 pg two to-three hours prior to the procedure efficacy was assessed by softening and dilatation of the cervix. The out come measures included successful termination without any complication and side effects. RESULTS: Mean dose required was 400 micrograms. The lime interval between the insertion of misoprostol and surgical procedure was 4 hours. Out of 100 patients 9` patient gave desired response to the medication (cervix become soft and dilated). In 4 patients the method was failed and required instrumental dilatation. 2 patient developed sever vaginal bleeding, so immediate dilation and evacuation was done. 2 patient developed fever with rigor and in 4 patients there were GIT symptoms. CONCLUSION: Intravaginal insertion of misoprostol prior to instrumentation in first trimester makes the intervention easier, shortens the time for procedure and reduces the complication.

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