Shahroona Masud, Fatima Mehboob, Muhammad Usman Bappi.
Severe hyperprolactinemia directly depresses the gonadal activity causing infertility.
Esculapio J Services Inst Med Sci Jan ;2(4):25-7.

Background: To quantify the degree of correlation between serum hormones (prolactin, FSH and testosterone) and sperm count in primary hypogonadism due to hyperprolactinemia in oligo/azoospermic infertile patients. Methods: Serum prolactin, FSH and testosterone levels of 100 male infertile oligospermic/ azoospermic patients were assayed by radioimmunoassay (RIA) and their data was analyzed for significant correlation with the same parameters of 20 control cases. Results: 25 out of 100 infertile patients had hyperprolactinemia out of which 13 had hypogonadism. Out of the 13 hyperprolactinemic hypogonadism cases, 9 had azoospermia. The values of serum prolactin and FSH were significantly raised (P<0.001). The sperm count in the group was strongly correlated to serum FSH (r = 0.67 P<0.05). Conclusion: Severe degree of hyperprolactinemia can cause infertility by inducing azoospermia directly. The levels of serum FSH rise in an attempt to reverse these changes.

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