Tania A Shakoori.
Bronchial hyperreactivity in chronic obstructive pulmonary disease.
Pak Armed Forces Med J Jan ;58(1):75-82.

Patients of chronic obstructive airway disease, who exhibit BHR, represent a distinct subgroup of COPD patients. The airway hyperresponsiveness is primarily the result of excessive airway smooth muscle contraction due to complex molecular mechanism. It is a risk factor for COPD and associated with increased morbidity and mortality. As the pathophysiolgical mechanisms of BHR in COPD are uncovered, a better understanding can be gained of this particular phenotype of COPD and better therapies formulated. This is a review article.

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