Ayesha Hafeez, Farooq Ahmad Khan, Abdus Sattar, Aamir Ejaz, Rizwan Hashim.
Frequency of dyslipidemia in women with polycystic ovary syndrome.
Pak J Pathol Jan ;18(4):105-9.

Introduction: The metabolic health implications of polycystic ovary syndrome (PCOS) including dyslipidaemia have been highlighted by a number of international studies. No local data is however available on the subject so far. Keeping in view the sparse data and the metabolic implications of the condition, there is a need to address the disease pattern in our peculiar genetic, ethnic and socio-economic group. Objective: To determine the frequency of dyslipidaemia in women with PCOS. Study design: Descriptive study. Place and duration of study: The study was conducted at Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi from Oct 2005 to Oct 2006. Subjects and methods: One hundred patients with PCOS were selected, who had been diagnosed as per Rotterdam ESHRE/ ASRM–sponsored PCOS consensus workshop criteria. After a detailed clinical history and physical examination, findings of hormonal/radiological investigations were recorded. Body mass index was calculated and blood sampling done for total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and lipoprotein (a) [(Lp(a)] in fasting state. Follicle stimulating hormone, luteinizing hormone (FSH), testosterone (Te), sex hormone binding globulin (SHBG), prolactin (PRL) and thyroid stimulating hormone (TSH) were analyzed in the patients for whom the results were not already available. Results: Seventy-one percent of the patients had at least one abnormal lipid level. Decreased/borderline HDL-C 0.9mmo1/1) was the most frequent lipid abnormality (58%), followed by raised TG (>2.26mmol/l) in 21%, raised Lp(a) (>30mg/dl) in 16%, elevated TC (>5.18mmol/l) in 12% and elevated LDL-C (>3.36mmol/l) in 11% of the patients. Conclusion: The frequency of dyslipidaemia in PCOS in terms of single abnormal lipid level approaches 71%, indicating a trend towards dyslipidaemia.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com