Zafar Lqbal, Ziaullah, Anita Basit, Mohammad Yousaf Khan, Arshad Javaid, Zafar lqbal.
Changes in arterial blood gases and respiratory rate before and after non invasive positive pressure ventilation in acute exacerbation of COPD.
Pak J Chest Med Jan ;14(3):3-8.

To compare Respiratory Rate, pH, pCO2 before and after Non Invasive Positive Pressure Ventilation in Acute Exacerbation of COPD Design of study: An Interventional study (Quasi Experimental) Place and duration of study: Pulmonology department of Post Graduate Medical Institute Lady Reading Hospital Peshawar, from Oct. 2003 to Oct, 2004. Material and methods: Fifty patients were recruited in the study. The patients were clinically assessed and relevant investigations done before starting on NIPPV. The parameters i.e. respiratory rate, pH and PCO2 were regularly monitored. The NIPPV was given for at least 6-8 hours in the first 24 hours. It was continued longer according to the patient response and tolerance. Clinical signs and arterial blood gases level were checked 6-8 hours after start of NIPPV. Results: The mean respiratory rate decreased from 24-16+ 3.47 per minute to 17.40+ 3.14 per minute (P <0.0001). There was significant improvement in pH from 7.28+ 4.39 to 7.35+8.28. (P <0.0001), and reduction in pCO2 from 63.750+ 10.01 mmHg to 56.22+11.40 mmHg, (P <0.0001). Conclusion: There were remarkable improvement in pH, PCO2 and respiratory rate after Non-Invasive positive pressure ventilation (NIPPV). NIPPV is a effective, simple and affordable addition to the treatment of life threatening chronic obstructive pulmonary disease.

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