Seyed Mohammad Alavi, Mohammad Said Seraj, Arash Etemadi, Moradzadegan H.
Frequency of HLA-B27 antigen in Iranian patients with brucellosis and it’s relationship with osteoarticular complication.
Pak J Med Sci Jan ;25(2):253-6.

ABSRACT Objectives: To determine frequency of HLA-B27 in brucellosis patients and to investigate a possible association between osteoarticular brucellosis and HLA-B27 antigen. Methodology: Sixty patients with serologically confirmed brucellosis and 100 healthy controls were screened for HLA-B27 by using standard microlymphocytotoxicity method. Osteoarticular involvement was suggested by clinical presentation and confirmed by nuclear scan. Patients were placed in two groups and compared, patients with osteoarticular involvement (OAP group) and without osteoarticular involvement (OAN group). All data were analyzed by SPSS (version11.5, USA) and using Fisher’s exact X2 test. Results: Out of total 60 patients with brucellosis 38(63.3%) were male. Mean age of the patients were 36.2±12.3 with the range of 18-65 years. HLA-B27 test was positive in 11 patients (18.33%) with brucellosis, whereas in control group HLA-B27 positivity was 7% (p<0.05).The prevalence of HLA-B27 in OAP and OAN groups was 33.33% and 8.33%, respectively (p<0.05). Conclusions: The prevalence of HLA-B27 in our brucellosis patients is higher than normal population and there is a significant association between HLA-B27 and brucellar osteoarthritis in the region of study.

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