Jahanzaib Haider, Shams Nadeem Alam, Muhammad Laiquz Zaman Khan, Masood Jawaid, Khalid Ahsan Malik.
Renal dysfunction in relation to causes of obstructive jaundice.
Pak J Surg Jan ;25(1):49-52.

Objective: To determine the frequency of renal impairment and its relation with the type of obstructive jaundice. Study Design: Descriptive case series. Setting & Duration: Department of Surgery, Unit II and Unit VI, Dow University of Health Sciences and Civil Hospital, Karachi from July 2007 to December 2008. Methodology: Forty three consecutive patients with obstructive jaundice were admitted and subjected to routine investigations and imaging for diagnostic evaluation. Outcome of interests were type of obstructive jaundice (benign or malignant) and renal impairment. Renal impairment was categorized into renal compromise and failure. Creatinine clearance (Cr24) was used to identify renal compromise. Renal failure was recognized if BUN to creatinine ratio was <20:1 and/or urine output <400 ml/day. The SPSS version 11 was applied to the data. Results: The overall rate of renal impairment was 30.2% including (18.6%) renal compromise and (11.6%) frank failure. Majority of renal compromise (16.3%) was noticed in pre-interventional period whereas most of the renal failure (701o) observed in post-interventional period. Renal impairment had a significant association with malignant pathology as compared to benign cause (p=0.013). Conclusion: Renal impairment is one of the major complications of obstructive jaundice and has high chance of occurrence if the cause of jaundice is malignant.

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