Mahfoozur Rahman, Hayee A.
Antithrombin levels in healthy Pakistani males.
Pak J Med Sci Jan ;25(3):345-8.

Objective: To determine the antigenic concentration and percent functional activity of antithrombin in healthy Pakistani males. Methodology: Over a period of one year, 50 healthy male volunteers divided into two age groups were tested for antithrombin levels by radial immunodiffusion(RID), at the Departments of Pathology King Edward Medical College and Postgraduate Medical Institute, Lahore. None of them were suffering from any acute or chronic disease, nor were taking any medications. Plasma samples were used to determine the antigenic and derived percent activity from NOR-Partigen* plates supplied by Dade Behring. Results: The younger group of healthy male volunteers (n=25), mean age 23.5 years showed a higher antithrombin concentration 46.7mg/dl or 155% functional activity: while the older volunteers (n=25), with mean age 44.0 years, showed 42.4 mg/dl concentration or 142% functional activity. The p value was insignificant between the groups (p> 0.05). Conclusions: The younger healthy individuals in our population show higher antithrombin concentration and functional activity, which tends to decrease insignificantly with age.

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