Attaul Aleem Bhatti, Aslam Khan, Syed Ather Enam, Rashid Jooma1.
Intrathecal use of polymyxin B for treatment of multi-resistant meningitis.
Pak J Neurological Sci Jan ;4(1):23-6.

Multi-resistant gram-negative nosocomial meningitis is a serious life-threatening infection presenting a therapeutic dilemma. We report a neurosurgical patient who developed a post-operative brain abscess due to multi-resistant Acinetobacter Iwoffii, sensitive only to polymyxin B. Successful management was accomplished by administration of intravenous and intrathecal polymyxin B. Rapid CSF sterilization occurred with excellent clinical recovery and without any serious side-effects related to polymyxin B. To our knowledge this is the first reported case of intrathecal use of polymyxin B from Pakistan.

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