Aleem, Mir Ahmad M Zamir, Riaz Ahmad Tasneem, Kaukab Sultana.
Comparison of free / total prostate specific antigen (PSA) in benign prostatic hyperplasia and carcinoma prostate.
J Allama Iqbal Med Coll Jan ;5(1):31-45.

BACKGROUND The aim of the present study was to find out the ratio of free to total prostate specific antigen (PSA) in patients of benign prostate hyperplasia (BPH) and carcinoma prostate. PSA is the best tumor marker produced by the prostate epithelial cells. It is expressed in both benign and malignant prostate. PSA helps in early detection of carcinoma prostate, the ratio of free to total prostate specific antigen (F/T PSA) is the better index for early detection in BPH and carcinoma prostate. MATERIAL AND METHODS Out of Sixty (60) patients, 30 patients of BPH and 30 of carcinoma prostate (More than 50 years of age) were included in the study. Blood samples (5 ml each) were taken and on serum free/ total PSA tests were performed by using F/T PSA kits (ELISA method) RESULTS Comparing ratio of free/ total PSA (Prostate Specific Antigen) in BPH and Carcinoma prostate, the ratio was lower in carcinoma prostate as compared to Benign Prostate Hyperplasia (BPH), but raised in both as compared to normal: CONCLUSION Free/ Total PSA ratio is an acceptable index for the non invasive differentiation of BPH and carcinoma prostate.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals -