Gule Raana, Rukhshan Khurshid, Mohammad Muslim, Mehjabeen Salim, Mohammad Mustansar, Sadia Zafar, Maimoona, Rabia, Zafar Ali Ch.
Creatinine clearence in the urine as a reference value of substances excreted by the kidney in patients with hypertension.
J Allama Iqbal Med Coll Jan ;7(4):55-8.

Background Alterations in kidney function, due either to primary renal disease or to inappropriate hormonal influences on the kidney, are a cardinal characteristic in all forms of hypertension, and lead to a reduced ability of the kidneys to excrete sodium and the consequent development of elevated arterial pressures. Objective: Present study tried to analyze the mild chronic renal insufficiency through the determination of creatinine clearance in patients with essential hypertension to reinforce the need to consider using this parameter in daily clinical practice. Main Out comes and Measure: We analyzed clinical and biochemical data from 20 male and 20 females with hypertension patients (BP=159/100 mm Hg) referred to medical unit of Sir Ganga Ram Hospital, Lahore from Jun 2007 to Dec 2007. Parameters used to estimate were the volume of urine, serum creatinine, urinary creatinine and urinary protein by standard kit (Merck) method. Creatinine clearance estimated by the Cockroft-Gault formula. Results: Level of serum creatinine and urinary creatinine were non significantly raised in both sexes of patients as compared to these values of normal subjects. Volume of urine was significantly decreased in male patients as compared to their normal control subjects. It is also observed that volume of urine in female patients was significantly increased as compared to male patients. Creatinine clearance was non significantly high in both group of patients when compared these values with the normal subjects. Level of urinary protein was non significantly increased in both sexes as compared to their control subjects. Conclusion: The finding of an altered renal function is associated with a significant increase in cardiovascular risk in hypertensive patients. It is therefore concluded that creatinine clearance should be abandoned as the routine assessment of glomerular function in patients with hypertension.

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