Noor M, Khan B, Iman N, Abdulla S, Mahmood S.
The frequency & causes of crescentic glomerulonephritis.
J Med Sci Jan ;17(1):50-2.

Objectives: The purpose of the study was to find out the frequency & causes of crescent glomerlonephritis in our setting. Material & Methods: The study was conducted at the Department of Medicine Khyber Teaching Hospital, Peshawar from July 2006 till December 2007. Kidney biopsies were performed with a disposable automated needle on a specific protocol and were sent to a single centre. Out of 130 kidney biopsies performed over this period 25 patients had crescentic glomerlonephritis and were selected for study. All analysis was performed on SPSS 13 and Chi square test was used for the significance of an association. Results: The total number of biopsy proven cases of crescentic glomerulonephritis were 25, out of whom 12 (48%) were male & 13 (52%) were female. The mean age was 35.32 ± 8.36 years. The underlying etiological diagnosis was systemic lupus erythematosis (SLE) in 13 (52%), microscopic polyangiatis in 4 (16%), Wegners granulomatosis in 3 (12%), endocapillary GN & IgA nephropathy in 2 (8%) each & Good pasture syndrome in 1 (4%). Sixty percent patients had proteinuria less than 3 grams/24 hours & 40% had more than 3 grams proteinuria. The mean urea level was 127 mg/dl ± 35.56 & mean creatinine level was 5.75 mg/dl ± 1.42. Gender had no statistically significant correlation with cANCA (p 0.28) & pANCA (p 0.125), while it had statistically significant correlation with presence of nephrotic range proteinuria (p 0.002), positivity for anti double stranded DNA (p 0.015) & anti nuclear factor (p 0.003). Conclusion: SLE was the commonest cause of crescentic glomerulonephritis in females & strong association with nephrotic range proteinurea and positivity for ANF & Anti d DNA.

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