Waseem Iqbal, Khalid Hassan, Nadeem Ikram, Samina Nur.
Aetiological Breakup in 208 Cases of Pancytopenia.
J Rawal Med Coll Jan ;5(1):7-10.

Pancytopenia is a serious haemotological problem, which makes the patient prone to anaemic manifestations, infections and bleeding tendency. Bone marrow biopsy plays a significant role in understanding the aetiology of pancytopenia, in patients who need a laboratory work up. In the present study on 208 consecutive cases of pancytopenia referred for bone marrow biopsy, megaloblastic anaemia (28.3%) was the commonest aetiological factor. It was followed by aplastic anaemia (22.1%), hypersplenism (14.4%), non-Hodgkin`s lymphoma (5.3%), acute lymphoblastic leukaemia (4.8%), leishmamiasis (4.8%), chronic underlying disorders - mostly infections (4.3%), acute myeloid leukaemia (3.8%), myelofibrosis (2.4%), sideroblastic anaemia (2.4%) and myelodysplastic syndrome (2.4%). Bone marrow aspiration and trephine biopsy were found to be useful diagnostic tools in evaluating the aetiology of pancytopenia.

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