Shahnaz Shams.
Treatment ENT with Biosynthetic Growth Hormone in Patients with Classic Growth Hormone Deficiency.
Pak Armed Forces Med J Jan ;45(2):22-5.

7 cases of classic growth hormone deficiency who were previously untreated, were treated with biosynthetic growth hormone. Their mean chronological age was 10.67 +/- 2.93 with height age of 5.51 +/- 3.53, bone age of 6.14 +/- 3.86 and with bone age lag of 48.85%. Mean pretreatment heigth velocity of these cases was 2.97 +/- 093cm/year. Biosynthetic hGH (Norditmpin and Genotropin) was administered in a dose of 12 units/m2/week at night time. After 1 year their mean height velocity had increased to 8.46 +/- 2.71 cm/year. Maximum increase in height was seen during second trimester of therapy.

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