Masood Ahmad Khan, Manzoor Ahmad, Sajid Mushtaq, Nadira Mamoon, Amir Hussain Khan.
Immunophenotypes of Diffuse Large Cell Lymphoma.
Pak Armed Forces Med J Jan ;45(2):32-7.
Diffuse large cell lymphoma (DL) comprised of heterogenous cell subtypes and is the most frequent type of non-Hodgkin's lymphoma in our material. A study to document immunophenotypes in 40 randomly selected cases was performed at AFIP Rawalpindi. The paraffin embedded material was used. Various B cell (L26), T cell (UCHL1 and MT1), histiocytic (Mac 387) and Ki-1 antigen (Ber H2) markers were utilized. The results suggested that 87.50% cases were positive for B cell marker. 5% of all DL cases studied were Ki-1 lymphomas while DL of true histiocytic origin were only 2.50% . No DL of T cell lineage could be detected in this series. More studies with larger pannel of cell markers are required to fully characterise the various immunophenotypes of DL in this region.
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