Nighat Kafil, Naila Irum Hadi, Bushra Waseem.
Comparison between glucosamine sulphate and nimesulide therapies in osteoarthritis.
J Surg Pak Jan ;15(2):97-102.

Objective To examine the effects of glucosamine sulphate and nimesulide on parameters such as pain at rest, pain on movement and limitation of movements in patients suffering from osteoarthritis (OA)of at least one knee joint. Study design Descriptive study. Place & Duration of study The study was conducted at Jinnah Postgaduate Medical Centre, Karachi. Study period was 90 days. Methodology Ninety patients of either sex, between 35 – 80 years suffering from OA of at least one knee joint were selected. Patients were divided into 3 groups, Group A, B, and C, of 30 patients each receiving capsule glucosamine sulphate (GS), tablet nimesulide and placebo treatment respectively. After the relevant radiological examination and laboratory tests the patients were asked to come for follow up visits fortnightly. Statistical analysis of data was performed on day 0, 30, 60 and 90. Parameters of pain at rest, pain on movement and limitation of movements were evaluated by 4-point scale and goniometer. Results Both glucosamine sulphate and nimesulide significantly reduced all the parameters at the end of the 90 days study period in comparison with placebo therapy. Conclusions The use of glucosamine sulphate or nimesulide may be beneficial for the patients of osteoarthritis suffering from pain at rest and movement and also improve range of movements.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com