Aftab Ahmed, Bashir Ahmad Junjua, Syed Faizul Hassan Rizvi, Zafar H Tanveer, Ijaz Ahmed.
Prevalence of hypomagnesaemia in patients with acute myocardial infarction compared with normal subjects.
J Sheikh Zayed Med Coll Jan ;1(4):122-4.

Background: Magnesium, the second most abundant intracellular cation has several clinically important roles in the human body. In addition to energy production and maintenance of electrolyte balance, Magnesium (Mg++) is essential for normal neuromuscular functions, excitation contraction coupling, maintenance of vascular tone, blood coagulation, as well as Ca++ and K+ transport across the plasma membrane. Mg++ has also important role to play in cardiovascular homeostasis. Objectives: To find out serum Mg++ levels in Acute Myocardial Infarction (AMI) patients at presentation to emergency departments and its comparison with normal subjects. Patients and Methods: This was a comparative study, conducted at Punjab Institute of Cardiology, Lahore from June to December 2000. A total of 125 subjects were enrolled for this study, with 88 patients having their first episode of AMI. These patients were divided into three groups A, B and C depending on age. 37 normal subjects were taken as comparative group. Results: There was hypomagnesemia (p< 0.001) in all the sub groups. Our results show that hypomagnesemia is present in all groups and as it is an important risk factor for post AMI complications. The corrective dose should not be empirical but be based on individual patient requirements, as mortality rate due to AMI and its complications is high. Conclusion: Hypomagnesemia was observed in all the sub groups A, B and C. Therefore, it is suggested that serum Magnesium should be estimated in each case of AMI patient and emphasis given to Mg++ supplementation when needed.

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