Jude A Onuegbu, Japhet M Olisekodiaka, Hassan A Oladele, Usman S Opeyemi, Christopher A Igbeneghu, Adetunji D Adeyeye.
Lipid profile of subjects infected with Schistosoma Haematobium in South - Western Nigeria.
Pak J Med Sci Jan ;27(1):44-7.

Objectives: To determine the plasma concentrations of total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) in Schistosoma haematobium- infected subjects and healthy persons. Methodology: The plasma concentration of lipids and the fractions with the urine microscopy of one hundred(100) subjects who had evidence of Schistosomiasis, selected from Ilie, a rural area in Osun State, Nigeria and one hundred (100) healthy controls selected randomly in Osogbo, an urban centre in Osun State, Nigeria were determined. Results: The age of the subjects ranged between 7-13 years with mean±SD of 11.00 (± 1.69) years and 10.5 (± 2.01) years for test subjects and controls respectively. The mean plasma concentration of triglyceride, total cholesterol, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were significantly lower among S. haematobium-infected subjects than in controls irrespective of the age and sex (p<0.01). Conclusion: Significantly lower plasma lipid levels found in infected subjects lend support to the hypothesis that schistosome eggs probably contribute to alteration of lipid profile through enhancing of LDL-uptake by macrophages.

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