Tariq Abbas, Aftab Ahmad Tarique, Saqib Shafi Sheikh, Muhammad Azhar.
A promising treatment of HOCM: percutaneous transluminal septal myocardial ablation (PTSMA).
J Cardiovascular Dis Jan ;1(1-2):38-41.

Treatment of symptomatic patients with Hypertrophic Obstructive Cardiomyopathy (HOCM) aims to reduce symptoms, improve function capacity and provide better quality of life. Medical therapy with administration of negative inotropes like betablockers, Verapamil or Disopyramide is just the treatment. Unfortunately, 10% of patients with marked outflow tract obstruction have severe symptoms that are unresponsive to medical therapy. In this group surgical treatment with Myectomy/Myotomy has been the main stay for decades with a reported mortality of 1.5-10% Dual chamber pacing was subsequently introduced as an alternate to surgery but it has not proven to be efficacious in randomized trials.Percutaneous transluminal septal myocardial ablation (PTSMA), through alcohol induced occlusion of septal branch, aims directly to reduce hypertrophied interventricular septum with expansion of Left ventricular out flow tract (LVOT) and reduction in LVOT gradient.

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