Tehseen Iqbal, Khemomal A Karira, Shehnaz A Sheikh.
Systemic lupus erythematosus, female of fertile age changes in reproductive hormones estrogen and prolactin levels.
Professional Med J Jan ;18(2):255-8.

Material and methods: Thirty five diagnosed cases of SLE and in addition 35 normal healthy controls from general population were included in the study. Serum levels of prolactin, estrogen, RA factor and ESR were estimated and correlated. Statistical analysis: The data was analyzed by using SPSS version 17. The student t-test & chi-square test was used the p-value <0.05 consider significant. Results: The results showed that patients suffering from SLE have highly significant (p<0.001) serum level of reproductive hormones prolactin and estrogen, in addition, significant changes in ESR indicate the infection when compared with control. Further, prolactin was negatively correlated with estrogen as well as with menarche while BMI have positively correlation with estrogen regardless of prolactin and menarche. Conclusions: Enhanced serum prolactin and estrogen changes in patients with systemic lupus erythematosus (SLE), may be used as a prognostic tool for autoimmune diseases.

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