Khurram Saleem, Mohammad Ali Yasin, Anser Asrar, Samina Qamar.
Comparison of repaglinide with glibenclamide in the reduction of HBA1C of type 2 diabetic patients.
Pak J Med Health Sci Jan ;5(1):23-6.

Objective: To evaluate the efficacy (glycemic control/HbA1C)) provided by repaglinide compared with glibenclamide in type 2 diabetic patients. Research Design & Methods: This single-center, randomized prospective study of one year duration was carried out in 100 patients aging between 30-70 years, all diagnosed to have type 2 diabetes mellitus recently and were not on any treatment. They were randomly categorized into two groups, repaglinide (test) and glibenclamide (control) groups. Repaglinide was given preprandially upto three times a day and glibenclamide was administered once or twice daily. Dosage was adjusted according to blood glucose level. Fasting blood glucose, two hours postprandial blood glucose, weight and blood pressure was recorded on every visit, while (HbA1c) was done thrice during the study (at the beginning, at six months and at the end of one year). Results: Of the hundred randomized patients (50 in each group), all showed a decrease in fasting blood glucose, two hours postprandial blood glucose and HbA1c. Mean reduction in fasting blood glucose by repaglinide group was 64 ± 53 and those by glibenclamide group was 34.7 ± 53 (P=0.007). The mean reduction in two hours postprandial blood glucose was 119 ± 66 in repaglinide group, while 87.6 ± 74 was observed in glibenclamide group (P=0.02). HbA1c mean reduction in both repaglinide and glibenclamide groups was 1.1 ± 0.3 and 0.7 ± 0.5 respectively (P=0.000). No statistically significant weight change was observed and no hypoglycaemic event was recorded in both the groups. Conclusion: The results suggest that repaglinide and glibenclamide both were effective in lowering fasting, two hours postprandial blood glucose and HbA1c if used regularly for one year. The effect of repaglinide in lowering HbA1c was impressive as compared to glibenclamide. Both the drugs were well tolerated and weight change was minimal in both groups.

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