Tahira Sadiq, Mohammad Fahd Baqai, Mohammad Tariq Baqai, Abdul Ghani Waseem, Khalid Kundi.
Haemoglobin defect, hbsd, with recurrent episodes of jaundice.
J Rawal Med Coll Jan ;15(1):61.

HbD Punjab, also known as HbD Los Angeles is a β-chain variant of HbD. It is characterized by Glu-Gln substitution at codon 121 with a GAA->CA A change at the DNA level and electrophoretic activity at alkaline pH, which is similar to HbS. Out of the 16 variants, HbD Punjab is the most common HbD variant. HbD has been described in homozygous and heterozygous forms. Heterozygous forms of HbS or HbD are usually silent. HbD Punjab interacts with HbS to produce mild haemolytic anaemia but cases have been reported with severe haemolytic anaemia and splenomegaly. It occurs in 1-3% of Western population. In the Indo-Pak subcontinent, HbD has been observed in 0.86% of the population, with a frequency of 3.6% in Punjab. 1,2 We describe a case report from Rawalpindi, Punjab-Pakistan, of HbSD disease with recurrent episodes of jaundice.

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