Tatheer Zahra, Shadab Ahmed Butt.
Effect of beta carotene on renal function tests of acetaminophen administered rats.
J Rawal Med Coll Jan ;14(2):93-5.

Background: Acetaminophen (APAP) induced nephrotoxicity has become an important problem due to the frequency with which it is used for self poisoning. Methods: In this randomized control trial, sixty young adult (4-6 weeks old) Sprague-Dawley rats weighing 180-240 g were randomized into three groups. Control group C was given standard National Institute of Health (NIH) laboratory diet, experimental group A was given toxic dose of APAP 700 mg/kg body weight once daily and experimental group B was given beta carotene 30 mg/kg body weight once daily one hour before 700 mg/kg body weight APAP once daily for seven days. Blood samples were collected 24 hours after the last dose for measurement of serum urea and creatinine levels. Results: Biochemical analysis showed significant difference in serum urea and creatinine levels in experimental group A as compared to control group. These levels in experimental group B were significantly different from experimental group A; but similar to control group C. Conclusion: Beta carotene has nephroprotective properties against APAP-induced nephrotoxicity in rats.

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