Mobina Ahsan Dodhy, Tahir Aziz Ahmad, Masood Anwar, Saleem Ahmad Siddiqui, Muhammad Farooq Khattak, Karamat Ahmed Karamat, Muhammad Saleem.
Frequency of HLA antibodies causing platelet refractoriness in patients undergoing chemotherapy.
Pak J Pathol Jan ;8(2):7-10.

Seventeen patients of various haematological malignancies receiving chemotherapy were studied to determine the frequency of platelet refractoriness in patients and to estimate the frequency of HLA antibodies as a cause of platelet refractoriness. The main outcome measures included development of platelet refractoriness and detection of HLA antibodies. Eight out of the 17 patients survived for a period required for the development of platelet refractoriness. Out of these only one patient developed clinical refractoriness to platelet transfusions. The serum of this patient showed significant lymphocytotoxicity against all HLA- and B antigens on donor lymphocyte panel.

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