Shagufta Hussain, Abdul Hannan.
In-vitro activity of older and newer 6-fluorinated quinolones against multiresistant clinical isolates.
Pak J Pathol Jan ;8(2):19-23.

Common gram negative and gram positive clinical isolates have become progressively more resistant in recent years to the clinical useful antibiotics. Such resistant isolates create therapeutic failures in clinical practice. Hence, there is a need for continuous search for new agents. A total of 533 multiresistant clinical isolates which included gentamicin resistant Escherichia coli, Klebsiella pneumoniae, Acinetobacter calcoaceticus, Proteus mirabilis, Enterobacter cloacae, Pseudomonas aeruginosa, chloramphenicol resistant Salmonella typhi and methicillin resistant Staphylococcus aureus (MRSA) were studied. Their in-vitro susceptibility to older and newer quinolones namely nalidixic acid, norfloxacin, ofloxacin, ciprofloxacin and pefloxacin was determined by agar dilution technique as minimum inhibitory concentrations (MICs). Ciprofloxacin has been found as the most active drug against almost all the isolates except for Acinetobacter calcoaceticus for which ofloxacin was the most potent of all the quinolones against all micro-organisms. Out of the eight generas tested, the MICs of all quinolones were lowest for Proteus mirabilis and Salmonella typhi. Nalidixic acid was ineffective against MRSA and Pseudomonas aeruginosa.

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