Manzoor Ahmad Malik, Tariq Mahmood, Junaid Habib Khan, Muhammad Irfan Shabbir Goraya, Asif Hanif, Imtiaz Akhtar Bajwa.
Comparison of the outcome of transurethral resection of prostate in terms of bleeding complications with and without preoperative finasteride.
Pak J Med Health Sci Jan ;4(4):533-6.

Objective: To compare the outcome of Transurethral Resection of Prostate in terms of bleeding complications, with and without preoperative Finasteride in the management of Benign Prostatic Hyperplasia. Subject and method: Total 100 patients selected and admitted through OPD after clinical diagnosis of BPH who require TURP. They were divided into two groups, each having 50 patients fulfilling the inclusion criteria. Group A patients were given oral Finasteride 5 mg OD at bed time , preoperatively for 2 weeks through OPD basis and then they were operated upon for TURP and the group B patients were operated without taking Finasteride preoperatively. The outcome of Transurethral Resection of Prostate in terms of bleeding complications was evaluated statistically. Results: It was noted that in group A (Finasteride group) , perioperative gross haematuria was 10 % (5 out of 50 patients ) and in group B , it was 36 %(18 out of 50 patients ).It was also noted that requirement of blood transfusion was 8 % (4 out of 50 patients ) in group A patients ,while it was 24 % ( 12 out of 50 patients ) in group B patients. Clot retention was 12 % (6 out of 50 patients ) in group A and 38 % ( 19 out of 50 patients ) in group B patients .Two patients out of 50 (4 % ) in group B ( without Finasteride ) required a return visit to operation room the control of bleeding surgically while none of the patients in group A ( 0 % ) required second visit to operation theatre for bleeding complication. Mortality was not observed in any case of both groups.

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