Saadia Ashraf, Mukhtiar Zaman, Nizamud Din.
The frequency of lung cancer in the tissue specimen at histopathological laboratory obtained through fiberoptic bronchoscope.
Pak J Chest Med Jan ;17(4):24-9.

Objective: To find out the diagnostic yield and frequency of lung cancer and its histological types in the tissue specimen taken through Fiber optic Bronchoscope. Methodology: All bronchoscopic biopsy specimens received from Jan 2003 to Dec 2005 at a renowned City Laboratory Peshawar for histopathological examination were included in the analysis. The data regarding age, sex, presence or absence of tissue in the specimen bottle and histopathological diagnosis was recorded. The specimens were examined by one histopathologist. Results: Total of 451 bronchoscopic biopsy specimens were received for histopathological analysis from hospitals and private clinics. There were 305 males (M) and 146 females (F) in the study sample with a mean age of 59 years. Twenty eight samples did not have sufficient tissue and were excluded from the analysis. Twenty four specimens were reported normal and 399 specimens has revealed pathology; 181 suggestive of malignancies, 173 were reported as chronic non- specific inflammation, 36 were reported as chronic granulomatous inflammation, 2 were reported as fungal infections, 2 fibrosis, 2 anthracosis, 1 aneurysm, 1 bronchial carcinoid and 1 focal metaplasia. In the 181 specimens suggestive of malignancy; 61 were squamous cell, 61 adenocarcinoma, 31 small cell, 4 large cell, 2 bronchoalveolar, 13 undifferentiated bronchial carcinoma, 1 Non- Hodgkin lymphoma and 8 others. Conclusion: Laboratory based diagnostic yield of the bronchoscopic bronchial biopsies is 88% and malignancy (45.4%) is the most frequent diagnosis in this study sample.

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