Mumtaz Begum, Khatoon Akthar Bano, Nasim Akhtar.
Effect of Oral Contraceptive Therapy and its duration on the Liver Functions.
Mother & Child Jan ;13(4):136-140.

Liver function tests were done in 75 females aged 20-40 year using oral contraceptives for 1-2-4 months and compared with 30 age matched controls. Use of any type of oral contraceptives either for 16 months (short term) or 6-24 months (long term), were associated with significantly higher levels of serum alkaline phosphatase, aspartate trasnaminase (AST), alanine transaminase (ALT), bilirubin and thymol turbidity as compared to controls. However. levels of these constituents of blood appear to be non-significantly different when compared among the two groups using oral contraceptives for short term and long. It is suggested that oral contraceptive drugs should be used with care and with proper investigation of the liver function before and during therapy.

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