Shahbaz Nazir, Naseem Rauf.
Dopaminergic Blockade and Prolactin Release.
Mother & Child Jan ;37(2):54-7.

This study was designed to reconfirm the role of dopaminergic blockade on endogenous prolactin (PRL) release. For this purpose, metoclopramide (MCP), a popularly used regulator of gastrointestinal motility, was administered to a group of female albino rats in a dose of 2 ug/body weight subcutaneously twice daily for a period of 10 days. Serum PRL levels were determined by radioimmunoassay (RIA) before and after the administration of the drug. The results were compared with pre-and post-treatment serum PRL levels of saline-injected controls. Metoclopramide injections led to significantly (P<0.001) raised serum PRL levels, reconfirming that MCP is a potent pharmacologic stimulator of PRL release. This dopaminergic blockade effect can be utilized in the investigation of hyperprolactinemia, which is associated with a high prevalence of infertility.

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