Shaikh K Muhammad, Bashir A Shaikh, Kouro M Gurbakshani, Aziz U Jalbani.
Frequency triple hepatitis (hepatitis B and C and D virus) in Hbsag positive patients.
Rawal Med J Jan ;37(2):142-7.

Objectives: To determine the frequency of triple hepatitis in HBsAg positive patients and observe its effect on liver function test and radiological parameters. Methods: 1713 HBsAg positive patients presenting at Hepatology Clinic of Chandka Medical College, Larkana from January 2008 to June 2011 were enrolled for study. After informed written consent, blood samples were drawn for detection of anti-HDV Antibodies, anti-HCV antibodies HBV DNA, HCV RNA and HDV RNA and liver function tests (LFT). Ultrasound of all patients was performed. Serological, biochemical and radiological profile of Triple Hepatitis (TH) positive and negative patients were compared. The data was analyzed using SPSS v 19. Results: Of 1713 patients, anti-HCV Ab was detected in 420 (24.5%), anti-HDVAb in 1116 (65.1%), HBV DNA in 308 (18%), HCV RNA in 148 (8.6%) and HDV RNA in 896 (52.3%). 268 (15.6%) had triple hepatitis (HBV+HCV+HDV). 220 (82.1%) of TH positive patients were male (p<0.000). LFT were significantly elevated and ultrasonological examination showed advanced chronic liver disease in triple hepatitis. Conclusion: Triple Hepatitis infection was found in 15.6% HBs Ag positive patients. More males were affected and infected patients had advanced liver disease. (Rawal Med J 2012;37:142-147).

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